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Anxiety and the Endocannabinoid System

Anxiety is a normal coping mechanism. However, in excess, it can be detrimental. More than just a situational response, anxiety disorders are characterized by a persistent and oftentimes irrational dread of everyday situations which can interfere with daily activities.

Forty million U.S. adults are affected by an anxiety-related disorder; however, the prevalence of these disorders should not diminish their impact.

Excessive anxiety is a central symptom of several neuropsychiatric disorders. It is also including generalized anxiety disorder (GAD), panic disorder (PD), post-traumatic stress disorder (PTSD), and obsessive-compulsive disorder (OCD). It is a complex disorder that can develop through various factors including genetics, brain chemistry, personality, and life events.

 

Anxiety and Emotional Response

Anxiety is our body’s response to an emotional situation. Biologically, anxiety activates our “fight or flight” response to warn us of potential threats.

During such time, norepinephrine and cortisol flood our system to boost to perception, reflexes, and speed. These chemicals increase the heart rate, blood flow to the muscles, and air flow. With chronic anxiety, the response is never deactivated, and the physical and emotional effects of anxiety remain.

 

Anxiety and the Endocannabinoid System

The endocannabinoid system (ECS) plays an integral role in regulating emotional response.

Specifically, the ECS supports nerve activity that determines our response to emotional or aversive events.

 

An Introduction to the ECS

In a previous blog, the endocannabinoid system is a biological system responsible for maintaining homeostasis. The ECS’s composition is of endocannabinoids, degradative enzymes, and cannabinoid receptors. Creation of endocannabinoids such as anandamide (“the bliss molecule”) and 2-arachidonoylglycerol (2AG) is by our body on demand in response to an imbalance. They interact with the cannabinoid receptors to direct the body back to proper functioning.

 

CB1 Receptors and Anxiety

CB1 receptors, which are primarily located on nerve endings, are one of the two major cannabinoid receptors.

Studies have found the activation of the CB1 receptor produces anxiolytic (anti-anxiety) effects.

When discussing conditioned fear, the effect of CB1 receptor activation is complex; however, CB1 receptor activation can reduce fear and prevent the activation of existing memories from the past. Additionally, CB1 receptor activation protects against the adverse effects of chronic stress, which can lead to anxiety. For this reason, CB1 receptor activation has been studied for anxiolytic drug development.

Endocannabinoids activate the CB1 receptor; therefore, a higher level of endocannabinoids can be beneficial for those with anxiety-related disorders. Additionally, chemicals that inhibit the FAAH enzyme from breaking down anandamide increase endocannabinoid availability and are also being studied for their anxiolytic effects.

 

Living with Anxiety

There are many ways to manage anxiety. However, less than 40% of those with an anxiety disorder seek treatment. Still today, there is a stigma surrounding mental illness that discourages those struggling from seeking help. We can help end the stigma of mental illness by having open conversations about mental health, encouraging mental health education, and showing compassion to those with a mental illness.

If you or a loved one is struggling with an anxiety disorder, we encourage you to learn more about the disorder and the options for treatment.

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